Precursors: • Oils • Very fine powders

Process

Matrix encapsulation is the ideal process to convert liquids or very fine powders into free flowing granulates or powders. To do so, oils are pre-emulsified in an aqueous solution. Powders are put in suspension or dispersed in a melt of the encapsulating medium.

The next step is

  • in the case of an aqueous emulsion/suspension, the drying of the external aqueous phase containing the dissolved matrix material
  • in the case of a melt emulsion/suspension, the solidification

This results in powders and granulates with a flexible choice of particles sizes between 20 and 5,000 µm.

The lipophilic liquid droplets enclosed in the granulate have, as a rule, an average diameter in the order of 1 µm. The liquid loading can be up to 50%.

Matrix encapsulation provides the enclosed liquid droplets with effective protection against oxidation (e.g. for omega-3 fish oils) and prevents direct contact with other components of a formulation where incompatibility would be troublesome (e.g. where there is a bleaching, reducing or oxidising agent). It also enables the controlled release of liquid or solid reagents (e.g. silicone anti-foaming agents, aromas and flavours, etc.) with the dissolution of a complex powder formulation in a “controlled-release” or “slow-release” mechanism.

Advantages

  • Free flowing granulates with up to 50% liquid loading
  • Gentle treatment of sensitive components
  • Protects particles from external influences
  • Protects particles from internal incompatibilities
  • Specific “controlled-release” and “slow-release” mechanisms
  • Improved storage stability
  • Particles suitable for tablet pressing (direct compression)